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  • Title: [Refractory hypertension--principles of combination therapy].
    Author: Hitzenberger G.
    Journal: Acta Med Austriaca; 1995; 22(3):43-5. PubMed ID: 8571749.
    Abstract:
    "Non response" to treatment of hypertension may have different reasons: it may be "physician-related" ("white coat hypertension"), of "patient related" (poor adherence to prescribed medication, alcohol abuse, obesity) and it may really be a "resistant hypertension". In such cases one should search for a primary disease. If no such disease is found one should--according to the time-factor--wait for several weeks before increasing the dose; later on one should switch to another drug with a different mechanism of action and, if necessary, use a rational combination.
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