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  • Title: Absence of sodium appetite in cyclophosphamide and DOCA treated house mice.
    Author: Pasley JN, Koike TI, Neldon HL.
    Journal: Pharmacol Biochem Behav; 1977 Mar; 6(3):265-7. PubMed ID: 857252.
    Abstract:
    Intraperitoneal administration of cyclophosphamide 100 mg/kg and 200 mg/kg significantly lowered plasma sodium and significantly increased plasma potassium but did not result in saline preference in a strain of wild-derived house mice given a choice between water and saline (0.15M) to drink. Deoxycorticosterone acetate treatment in dosages up to 1.5 mg for four days also failed to increase salt intake, The data suggest a possible absence of a sodium appetite mechanism in this species.
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