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  • Title: Rhinocerebral mucormycosis. Therapy with amphotericin B lipid complex.
    Author: Strasser MD, Kennedy RJ, Adam RD.
    Journal: Arch Intern Med; 1996 Feb 12; 156(3):337-9. PubMed ID: 8572846.
    Abstract:
    Rhinocerebral mucormycosis with intracranial involvement has a high mortality. The standard therapy consists of aggressive surgical débridement accompanied by high doses of amphotericin B deoxycholate. Even with this therapy, the mortality rate has been 48% in the series reported since 1980. We treated a 60-year-old diabetic woman with rhinocerebral mucormycosis involving the cavernous sinus whose infection responded to medical therapy with amphotericin B lipid complex. To our knowledge, this is the only well-documented medical cure of a patient with rhinocerebral mucormycosis and intracranial involvement.
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