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  • Title: Bovine growth hormone induces oscillations in cytosolic free Ca2+ in single rat hepatocytes.
    Author: Marrero I, Green AK, Cobbold PH, Dixon CJ.
    Journal: Biochem J; 1996 Jan 15; 313 ( Pt 2)(Pt 2):525-8. PubMed ID: 8573087.
    Abstract:
    Single rat hepatocytes microinjected with the photoprotein aequorin generate oscillations in the cytosolic free Ca2+ concentration ([Ca2+]i) when stimulated with agonists acting through the phosphoinositide signalling pathway. We show here that, in single rat hepatocytes, bovine growth hormone (bGH) is able to induce [Ca2+]i oscillations which display similarities with oscillations induced by phenylephrine. Thus the rate of rise of intracellular Ca2+ in each oscillation closely resembles that induced by Ins(1,4,5)P3-mediated agonists. However, the duration of bGH-induced oscillations increases with agonist concentration, in contrast to phenylephrine-induced oscillations, which undergo an increase in frequency as the agonist concentration is raised, without any increase in the duration of individual oscillations.
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