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  • Title: Spectrofluorimetric determination of paracetamol in pharmaceuticals and biological fluids.
    Author: Vilchez JL, Blanc R, Avidad R, Navalón A.
    Journal: J Pharm Biomed Anal; 1995 Aug; 13(9):1119-25. PubMed ID: 8573637.
    Abstract:
    A spectrofluorimetric method for the determination of paracetamol is presented, based on the oxidation of the analyte to give the fluorophore 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl. Sodium hypochlorite was used as an oxidizing reagent and the optimum pH was found to be 10.0 (sodium carbonate-boric acid buffer solution). The linear concentration range of application was 0.1-100.0 micrograms ml-1 of paracetamol, the detection limit 0.01 micrograms ml-1 and the relative standard deviation 1.2%. The method has been satisfactorily applied to the determination of paracetamol in pharmaceutical formulations and biological fluids.
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