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  • Title: Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes.
    Author: Malva JO, Ambrósio AF, Carvalho AP, Duarte CB, Carvalho CM.
    Journal: Brain Res; 1995 Oct 23; 696(1-2):242-5. PubMed ID: 8574675.
    Abstract:
    Using Ca2+ channel toxins, we determined the types of voltage-sensitive calcium channels activated by two levels of KCl depolarization in hippocampal synaptosomes. The increase in the intracellular Ca2+ concentration ([Ca2+]i) induced by 30 mM KCl was equally sensitive to either omega-agatoxin IVA (omega-Aga IVA) or to omega-conotoxin MVIIC (omega-CgTx MVIIC), and the inhibition produced by these two peptides was not additive. The present results indicate that omega-Aga IVA and omega-CgTx MVIIC do not distinguish between two different VSCC in hippocampal synaptosomes and that they both inhibit a channel with the alpha 1A subunit which is present in the rat hippocampus.
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