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  • Title: Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis.
    Author: LeBlanc M, Neuwirth L, Mauragis D, Klapstein E, Tran T.
    Journal: Equine Vet J; 1994 Jul; 26(4):279-82. PubMed ID: 8575394.
    Abstract:
    The effects of oxytocin on the percentage of technetium 99m albumin colloid (99mTc-microAA), cleared from the uterine lumen was measured in 13 mares. Scintigraphy was performed during 4 consecutive oestrous cycles, on Day 3 of oestrus during Cycles one and 3 and 48 h after ovulation during Cycles 2 and 4. Oxytocin (20 iu) was given i.v. after the initial scintigraphy image during Cycles 3 and 4. Seven multiparous mares (Group 1) were classified as 'susceptible' and 6 mares (2 nulliparous and 4 multiparous; Group 2) were classified as 'resistant' to endometritis. All mares cleared > 90% of 99mTc-microAA within 30 min of oxytocin injection. When no drug was given, Group 1 mares cleared negligible amounts of radiocolloid (< 5%) and Group 2 mares cleared 50-80%. No mares showed signs of colic after oxytocin administration. It is concluded that oxytocin enhances uterine clearance of radiocolloid and may be useful for treating mares exhibiting impaired uterine clearance.
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