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  • Title: Effect of 1,10-phenanthroline on DNA binding by 1,25-(OH)2 vitamin D receptor.
    Author: Atkins KB, Beitz DC.
    Journal: Horm Metab Res; 1995 Oct; 27(10):455-60. PubMed ID: 8575724.
    Abstract:
    The effect of the chelator 1,10-phenanthroline on the DNA-binding of 1,25-dihydroxyvitamin D receptor was demonstrated. Increasing concentrations of the chelator, up to 3 mM, decreased receptor binding to DNA-cellulose. This effect was specific for the chelating function because the nonchelating analog, 1,7-phenanthroline, did not inhibit DNA-cellulose binding of the receptor. The cations Cd2+ and Zn2+ were able to block chelator-mediated inhibition. These cations were unable to reverse the inhibition unless 1,10-phenanthroline was removed by dialysis.
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