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  • Title: CD8+ T cell subsets in aging.
    Author: Ruiz M, Esparza B, Pérez C, Barranquero M, Sabino E, Merino F.
    Journal: Immunol Invest; 1995 Nov; 24(6):891-5. PubMed ID: 8575835.
    Abstract:
    Infections are major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes -which play a crucial role in host defence against viral infections-. are divided in subsets based upon the expression of several cell and activation markers. Since in senescence changes in peripheral blood CD8+ T lymphocyte compartment have been described, studies were performed to determine whether in aging there are variations in the peripheral blood CD8+CD38+, CD8+CD57+, CD8+HLA-DR+, CD8+CD45RA+ and CD8+CD45RO+ cell subset. A decrease in the CD8+CD45RA+ lymphocytes was observed, indicating that variations in the CD8+ compartment can take place with ageing.
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