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  • Title: Immunocytochemical mapping of serotonin and neuropeptides in the accessory medulla of the locust, Schistocerca gregaria.
    Author: Würden S, Homberg U.
    Journal: J Comp Neurol; 1995 Nov 20; 362(3):305-19. PubMed ID: 8576441.
    Abstract:
    Accumulating evidence suggests that pigment-dispersing hormone-immunoreactive neurons with ramifications in the accessory medulla of the insect brain are involved in circadian pacemaking functions. We have used immunocytochemical techniques to investigate the neurochemical organization of the accessory medulla in the locust Schistocerca gregaria. Local neurons with arborizations largely restricted to the accessory medulla are immunoreactive with antisera against serotonin, Manduca sexta allatotropin, and Diploptera punctata allatostatin 7. Projection neurons with arborizations in the accessory medulla and fibers to the lamina and/or several areas in the midbrain including the posterior optic tubercles, the inferior and the superior protocerebrum show Phe-Met-Arg-Phe (FMRF)amide-, gastrin/cholecystokinin-, crustacean cardioactive peptide-, and substance P immunoreactivities. A unique neuron with tangential ramifications in the medulla and lamina and varicose terminals in the accessory medulla contains a peptide related to locustatachykinin I/II. Double-label experiments show colocalization of pigment-dispersing hormone-immunoreactivity with substances related to gastrin/cholecystokinin, FMRFamide, substance P, or crustacean cardioactive peptide in certain projection neurons of the accessory medulla. The results suggest that neuropeptides and biogenic amines play major neuroactive roles in the accessory medulla of the locust. The abundance and extensive colocalization of neuropeptides in the locust accessory medulla is discussed with respect to the possible involvement of this brain area in circadian pacemaking functions.
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