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  • Title: Role of antineural antibodies in perpetuation of a pre-existing peripheral nerve damage in leprosy.
    Author: Desikan P, Parkash O, Narang P.
    Journal: Indian J Lepr; 1995; 67(3):293-300. PubMed ID: 8576608.
    Abstract:
    This study was carried out in order to find out whether antineural antibodies had a role to play in perpetuating pre-existing nerve damage in leprosy. Indirect ELISA was carried out on sera from 20 leprosy patients and five normal controls using antigen prepared from peripheral nerves of a cured bacteriologically negative leprosy patient. None of the patients had significant levels of IgG antibodies whereas eight of them (40%) had significant levels of IgM antibodies. However, there was no correlation with duration of disease, treatment received, nerve enlargement or active neuritis. The nature of these antibodies is discussed.
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