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  • Title: Postoperative nausea vomiting (PONV): influence of bowel manipulation during intraabdominal surgery.
    Author: Sirivanasandha P.
    Journal: J Med Assoc Thai; 1995 Oct; 78(10):547-53. PubMed ID: 8576662.
    Abstract:
    This study does not confirm the hypothesis that "bowel manipulation during intraabdominal surgery may release 5 HT3 to stimulate the vomiting center via the vagus nerve". Thus routine prophylactic use of 5 HT3 receptor antagonist is probably not necessary, especially in Thai patients whose PONV is not distinct both in incidence and intensity of emesis.
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