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  • Title: Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. One year of therapy.
    Author: Virgili A, Corazza M, Bianchi A, Mollica G, Califano A.
    Journal: J Reprod Med; 1995 Sep; 40(9):614-8. PubMed ID: 8576875.
    Abstract:
    OBJECTIVE: To study the use of topical tretinoin for treating vulvar lichen sclerosus. STUDY DESIGN: An open, uncontrolled clinical study on 22 patients affected by histologically confirmed vulvar lichen sclerosus. Topical 0.025% tretinoin was applied once a day, five days a week, for one year. Clinical and histologic parameters were evaluated before and after therapy, and statistical analysis was performed. RESULTS: Symptoms, gross appearance and histopathologic features improved in a highly significant manner (P < .001). Cutaneous side effects were observed but rapidly disappeared, and no patient left the study for this reason. Maintenance of results was observed at the 4-13-month follow-up visits. CONCLUSION: Topical tretinoin seems feasible for use in the topical treatment of vulvar lichen sclerosus.
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