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  • Title: [Immunology of tuberculosis].
    Author: Kaufmann SH.
    Journal: Pneumologie; 1995 Dec; 49 Suppl 3():643-8. PubMed ID: 8577669.
    Abstract:
    Protective immunity against Mycobacterium tuberculosis is mediated by specific T lymphocytes and executed by mononuclear phagocytes. The crosstalk between distinct T cell subsets and macrophages involves various cytokines. Attraction of blood monocytes to the site of mycobacterial replication and local macrophage activation result in granuloma formation. Interactions between T cell subsets and macrophages within granulomas enable the host to restrict mycobacterial growth, but only rarely cause sterile eradication. Therefore, at later time points, active tuberculosis may develop as a consequence of weakened immunity.
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