These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of castration on metalloprotease activities in the lateral, dorsal, and anterior lobes of the rat prostate.
    Author: Wilson MJ, Norris H, Woodson M, Sinha AA.
    Journal: Arch Androl; 1995; 35(2):119-25. PubMed ID: 8579472.
    Abstract:
    Several proteolytic enzymes are involved in mediating the regression of the prostate gland following castration. A previous study showed that plasminogen activator activities are elevated only in the ventral lobe by castration in the rat. Since matrix metalloproteases represent a different class of protease that degrade extracellular matrix, this study examined their activities in the lateral, dorsal, and anterior lobes of the rat in response to androgen deprivation. The results indicate that, in contrast to plasminogen activators, metalloprotease activities are increased in the lateral, dorsal, and anterior lobes following orchiectomy. This suggests that differences in regulation of certain proteases by androgens may occur in individual prostatic lobes.
    [Abstract] [Full Text] [Related] [New Search]