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  • Title: Anti-sense oligodeoxynucleoside phosphorothioates nonspecifically inhibit invasion of red blood cells by malaria parasites.
    Author: Ramasamy R, Kanagaratnam R, Misiura K, Rebowski G, Amerakoon R, Stec WJ.
    Journal: Biochem Biophys Res Commun; 1996 Jan 26; 218(3):930-3. PubMed ID: 8579616.
    Abstract:
    Anti-sense and sense oligodeoxynucleoside phosphorothioates, based on analysis of the secondary structure of Plasmodium falciparumdihydrofolate reductase-thymidylate synthase mRNA, were synthesized. Their effects on P. falciparum growth in vitro were examined by microscopy and [3H] hypoxanthine incorporation. Both anti-sense and sense oligodeoxynucleoside phosphorothioates inhibit invasion of red blood cells by merozoites and this is interpreted as being caused by their polyanionic nature. Specific anti-sense effects of the oligonucleoside phosphorothioates could not however be demonstrated.
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