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  • Title: [Effect of chronic administration of carbon tetrachloride on turnover of individual RNA fractions in rat liver tissue].
    Author: Ivanov SD, Voronova LA, Pirozhkov MA.
    Journal: Biull Eksp Biol Med; 1977 Apr; 83(4):423-5. PubMed ID: 857968.
    Abstract:
    During the carbon tetrachloride treatment of rats (for 24 weeks) the 5-H3-uridine content and incorporation into different rat liver RNA fractions after a short-term exposure of labeled precursor were studied. These fractions were obtained by preparative 2.5% polyacrylamide gel electrophoresis from the nuclear and cytoplasmic RNA extracted by thermal phenol fractionation. CCl4 administration resulted in a decrease in the level of transfer and ribosomal RNAs in the rat liver. Chronic CCl4 treatment led to disturbances of the turnover simultaneousness of different components of rapidly labled RNA.
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