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  • Title: Scavenging of free-radicals and inhibition of lipid peroxidation by 3-phenylsydnone.
    Author: Narla RS, Rao MN.
    Journal: J Pharm Pharmacol; 1995 Aug; 47(8):623-5. PubMed ID: 8583360.
    Abstract:
    The antioxidant properties of 3-phenylsydnone were studied in various models in-vitro. 3-Phenylsydnone scavenged the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, and inhibited the degradation of deoxyribose mediated by hydroxyl radicals, although, to a lesser extent than trolox, a water soluble analogue of vitamin E. Many antioxidants possess pro-oxidant properties due to their ability to reduce ferric ions; however, 3-phenylsydnone was free from pro-oxidant properties, and also inhibited the lipid peroxidation induced by iron, in rat brain homogenates.
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