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  • Title: Coexpression of vasoactive intestinal peptide, calcitonin gene-related peptide and substance P immunoreactivity in parasympathetic neurons of the rhesus monkey lung.
    Author: Nohr D, Eiden LE, Weihe E.
    Journal: Neurosci Lett; 1995 Oct 13; 199(1):25-8. PubMed ID: 8584218.
    Abstract:
    By the use of light microscopic immunohistochemistry, the present study investigates whether substance P (SP) and calcitonin gene-related peptide (CGRP), which are well documented neurotransmitter candidates in primary sensory fibers, are also expressed in parasympathetic neurons of the rhesus monkey lung. A combination of double fluorescence immunohistochemistry and staining of adjacent sections revealed triple coexistence of SP, CGRP and the cholinergic co-transmitter vasoactive intestinal peptide (VIP) in a large number of neuronal cell bodies in intrinsic peribronchial ganglia. In addition, there was co-localization of SP and CGRP in choline acetyl-transferase (ChAT)-positive neurons. These data suggest that SP and CGRP, in addition to their sensory role, are cholinergic cotransmitter candidates in the postganglionic parasympathetic innervation of primate lung. Co-release and co-function of SP and CGRP with VIP and acetylcholine may be important in the regulation of pulmonary physiology and in pulmonary pathophysiology.
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