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  • Title: [Mechanisms of mobilization of intracellular stored calcium].
    Author: Li HW, Wang X, Han QD.
    Journal: Sheng Li Ke Xue Jin Zhan; 1995 Jul; 26(3):209-12. PubMed ID: 8584885.
    Abstract:
    The release of intracellular stored Ca2+ is mainly regulated by an inositol 1,4,5-triphosphate (IP3) receptor system and a ryanodine receptor system. The former induces Ca2+ release directly when the receptors are bound to IP3. The later may function through the Ca2+ induced Ca2+ release mechanism when the ryanodine receptors are activated. Cyclic ADP ribose, a metabolite of NAD+ which is regulated by complicated mechanisms, is one of the most important factors causing activation of ryanodine receptors. The two systems may interact with each other to regulate Ca2+ release from intracellular calcium pool.
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