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  • Title: [Expression and localization of immediate early genes and preproenkephalin gene in central nervous system following electroacupuncture stimulation].
    Author: Cui X.
    Journal: Sheng Li Ke Xue Jin Zhan; 1995 Jul; 26(3):230-2. PubMed ID: 8584889.
    Abstract:
    Using the techniques of immunohistochemistry, Northern blotting and in situ hybridization, we have found that electroacupuncture (2/15Hz) accelerated the expression of mRNA and protein synthesis of immediate early genes c-fos, c-jun as well as proenkephalin gene in rat central nervous system (CNS). Northern hybridization revealed that EA stimulation induced c-fos gene expression within 1-2 h, followed by PENK gene expression which peaked at 48h. Morphological study demonstrated that the sites of c-fos, c-jun and PENK mRNA expression and protein synthesis coincide with each other in the CNS. The results suggest that Fos/Jun may function as the transcription regulator of PENK gene.
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