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  • Title: Tolerability and kinetics of a solvent-detergent-treated intravenous immunoglobulin preparation in hypogammaglobulinaemia patients.
    Author: Ebeling F, Baer M, Hormila P, Järventie G, Koistinen P, Kätkä K, Oksanen K, Perkkiö M, Ruutu T, Soppi E.
    Journal: Vox Sang; 1995; 69(2):91-4. PubMed ID: 8585206.
    Abstract:
    The tolerability and kinetics of a solvent-detergent-treated 6% intravenous immunoglobulin (IVIG) preparation were studied in 15 hypogammaglobulinaemia patients during 3-4 regular substitution infusions of 9-48 g, the mean dose being 359 mg/kg. The infusions were well tolerated, and the trough serum IgG levels achieved were comparable to two commercial IVIG preparations. The stepwise increase of the infusion rate up to 5 mg/kg/min and the use of this IVIG as a 12% solution were possible without serious adverse events in all the 6 studied hypogammaglobulinaemia patients. This greatly reduced the time needed for the infusions.
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