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  • Title: Staphylococcus aureus endocarditis in Danish intravenous drug users: high proportion of left-sided endocarditis.
    Author: Faber M, Frimodt-Møller N, Espersen F, Skinhøj P, Rosdahl V.
    Journal: Scand J Infect Dis; 1995; 27(5):483-7. PubMed ID: 8588139.
    Abstract:
    In a retrospective study covering the years 1982-1989 episodes of Staphylococcus aureus endocarditis in 51 intravenous drug users were studied. Tricuspid involvement dominated (34/51), but the frequency of left-sided involvement (33.3%) was greater than in earlier reports. Involvement of both sides of the heart was not detected, but 27.8% of the left-sided endocarditis cases had multiple pulmonary infiltrates, indicating that some of them might have had a concomitant right-sided endocarditis. The 2 groups were compared: patients with left-sided endocarditis were significantly older and with a longer time of intravenous drug use. The complication rate was the same (44.1%) as was the duration of antibiotic treatment (median 42 days). In total, five patients underwent surgery, two (5.8%) due to right-sided failure and three (29.4%) because of left-sided endocarditis. The mortality of tricuspid endocarditis was low (2.9%), whereas 5 patients (29.4%) with left-sided involvement died. The patients who died were significantly older and had a shorter duration of symptoms before hospitalization.
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