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  • Title: Histophysiological evidence for parathyroid mediation of estrogen- and prolactin-induced hypercalcemia in the toad Bufo melanostictus (Schneider).
    Author: Akbarsha MA, Palanisamy M, Manivannan B.
    Journal: Acta Physiol Hung; 1995; 83(2):171-9. PubMed ID: 8588504.
    Abstract:
    Administration of estrogen as well as prolactin to B. melanostictus resulted in hypercalcemia. Parathyroids and ultimobranchials of the toad were hypertrophied and the secretory epithelium reflected hyperplasia. Histophysiological manifestation of the parathyroids of treated toads suggests that estrogen and prolactin bring about hypercalcemia by stimulating the parathyroids. Changes in the ultimobranchials suggest hyperactivity of the gland to combat estrogen- and prolactin-induced hypercalcemia.
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