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  • Title: The influence of proline analogs on bleomycin-induced lung injury in rats.
    Author: Ledwozyw A.
    Journal: Acta Physiol Hung; 1995; 83(2):195-202. PubMed ID: 8588507.
    Abstract:
    The influence of 3,4-dehydro-DL-proline and 3,4-dehydro-L-proline on lysyl oxidase, prolyl hydroxylase activities, collagen cross-linking and types of collagen in bleomycin-induced lung injury was investigated. Both proline analogs cause a great fall in prolyl hydroxylase activity without effect on lysyl oxidase, diminish the number of cross-links and normalize the type I/type III collagen ratio. It is suggested that proline analogs may be valuable agents in lung fibrosis treatment.
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