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Title: Neutropenia induced by systemic infusion of chemotactic factors. Author: O'Flaherty JT, Showell HJ, Ward PA. Journal: J Immunol; 1977 May; 118(5):1586-9. PubMed ID: 858915. Abstract: Autologous plasma, when exposed to complement-activating agents that generate leukotactic activity, induces transient neutropenia after infusion into rabbits. Trypsinized human C5 as well as the chemotactic fragment isolated from zymosan-activated human serum also induces transient neutropenia in rabbits, as do chemotactically active synthetic tripeptides. In each instance the neutropenia-inducing activity parallels the chemotactic activity. Thus, neutropenia-inducing activity and chemotactic activity seem to be related physiologic responses of neutrophils. In vivo margination and/or agglutination of leukocytes may underlie this phenomenon of neutropenia.[Abstract] [Full Text] [Related] [New Search]