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  • Title: Stimulatory effects of fibronectin and EGF on migration of corneal epithelial cells.
    Author: Watanabe K, Nakagawa S, Nishida T.
    Journal: Invest Ophthalmol Vis Sci; 1987 Feb; 28(2):205-11. PubMed ID: 8591897.
    Abstract:
    The effects of fibronectin and epidermal growth factor (EGF) on the migration of corneal epithelial cells in situ were investigated. When rabbit corneal blocks were cultured in serum-free medium with fibronectin or EGF, corneal epithelial cells migrated on the cut surface of the stroma. Histological and electron microscopic studies revealed that the leading edge of the fibronectin-treated cornea was thin, single-layered epithelium, whereas the leading edge of the EGF-treated cornea was a hypertrophic, multilayered epithelium. By autoradiography with 3H-thymidine, the authors observed that EGF stimulated corneal epithelial cell proliferation; however, fibronectin had no effect on cell proliferation. These results demonstrate that fibronectin and EGF enhance migration of corneal epithelial cells in different ways: Fibronectin facilitates sliding of epithelium, whereas EGF increases cell proliferation.
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