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  • Title: Cellular fibroma of the ovary with Meigs' syndrome and elevated CA-125. A case report.
    Author: Siddiqui M, Toub DB.
    Journal: J Reprod Med; 1995 Nov; 40(11):817-9. PubMed ID: 8592321.
    Abstract:
    BACKGROUND: Cellular fibroma of the ovary is an uncommon benign tumor. When associated with Meigs' syndrome, it can produce a clinical picture similar to that of ovarian carcinoma. CASE: A 73-year-old nulligravida was admitted to the hospital with progressive cachexia, ascites, a right pleural effusion and a 15-cm pelvic mass. The serum CA-125 level was 1,780. Due to a high suspicion of ovarian carcinoma, the patient underwent exploratory laparotomy, total abdominal hysterectomy/bilateral salpingooophorectomy and surgical staging for a frozen section diagnosis of sarcoma. Permanent histology revealed the tumor to be a cellular fibroma, and the CA-125 levels fell to normal postoperatively. CONCLUSION: Since benign ovarian tumors may mimic carcinoma, laparotomy and appropriate surgical staging are essential for the final diagnosis.
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