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  • Title: Sodwanones G, H, and I, new cytotoxic triterpenes from a marine sponge.
    Author: Rudi A, Goldberg I, Stein Z, Kashman Y, Benayahu Y, Schleyer M, Garcia Gravalos MD.
    Journal: J Nat Prod; 1995 Nov; 58(11):1702-12. PubMed ID: 8594147.
    Abstract:
    Three cytotoxic triterpenes, sodwanones G [5], H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC50 values between 20 and 0.02 microM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).
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