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  • Title: Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus.
    Author: Matsuoka Y, Kitamura Y, Tsukahara T, Terai K, Tooyama I, Kimura H, Taniguchi T.
    Journal: Neuroreport; 1995 Nov 13; 6(16):2205-8. PubMed ID: 8595203.
    Abstract:
    Models of cerebral ischaemia were used for analysis of mechanism of neuronal cell death and/or damage. Ischaemia is caused dominantly by severe hypoxia and hypoglycaemia: in the present study, we examined the influence of severe in vivo hypoxia (5% O2/95% N2 for 30 min at 22 degrees C). After hypoxia, neuronal damage was observed in the CA3 and dentate gyrus (DG) after 3 and 21 days of survival, but not in the CA1.2,3-Dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX), an antagonist for AMPA/kainate receptors, showed neuroprotective effects in the CA3 and DG. These results suggest that hypoxia may induce neuronal damage in the CA3 and DG through activation of AMPA/kainate receptors.
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