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  • Title: Effect of MaxEPA (fish oil) on lipoproteins and its receptors in hypercholesterolemic rabbits.
    Author: Achtani C, Awtade A, Vasisht S, Srivastava LM.
    Journal: Biochem Mol Biol Int; 1995 Oct; 37(3):489-98. PubMed ID: 8595389.
    Abstract:
    The effect of dietary MaxEPA (fish oil) supplementation on cholesterol induced hypercholesterolemia in rabbits was investigated. Rabbits were fed 0.1% cholesterol enriched diet for one month and randomly divided into two groups (I and II). Group I was continued on a 0.1% cholesterol rich diet whereas group II in addition to cholesterol supplementation received MaxEPA (2.5 g/kg body weight) per day for a period of two months. B-VLDL-C, LDL-C and total serum peroxide levels (TBARS) were significantly higher in group II animals as compared to group I. No statistical difference was found in the number of hepatic B-VLDL binding sites between group I and II. Microscopic examination of the aorta showed an increase in the number of intimal foam cells in MaxEPA treated group, a result that may be linked to increase in total cholesterol, plasma TBARS and with simultaneous reduced hepatic uptake of B-VLDL.
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