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  • Title: [Contribution of immunotyping in the diagnosis and in the prognosis of acute leukemia].
    Author: Merle-Béral H, Boucheix C.
    Journal: Rev Prat; 1996 Jan 01; 46(1):30-6. PubMed ID: 8596888.
    Abstract:
    Characterisation of acute leukaemia has greatly progressed due to the discovery of a large number of molecules using monoclonal antibody techniques. In acute lymphoblastic leukaemia, these techniques not only demonstrate the lymphoid origin of the proliferation but also allow to distinguish between T and B lymphoblasts at various stages of differentiation. This information is useful in establishing prognosis and making therapeutic choices. In acute myeloid leukaemia, immunologic phenotyping confirms the French-American-British (FAB) classification, allowing diagnosis of undifferentiated acute myeloid leukaemia (LAM 0) and can itself constitute a prognostic element.
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