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  • Title: Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster.
    Author: Ferradini L, Gu H, De Smet A, Rajewsky K, Reynaud CA, Weill JC.
    Journal: Science; 1996 Mar 08; 271(5254):1416-20. PubMed ID: 8596914.
    Abstract:
    Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken lambda light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement. Here, mutation of the mouse homolog of a chicken element, located in the V(K)-J(K) intervening sequence upstream of the J(K) cluster, was shown to significantly decrease rearrangement. This cis-acting recombination-enhancing element affects the rearrangement process without being involved in regulating transcription.
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