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  • Title: The rosette complex in gerbil Deiters cells contains gamma actin.
    Author: Nakazawa K, Schulte BA, Spicer SS.
    Journal: Hear Res; 1995 Sep; 89(1-2):121-9. PubMed ID: 8600116.
    Abstract:
    The relationship of selected cytoskeletal elements with the rosette complex of Deiters cells was examined immunocytochemically in the gerbil cochlea. By light microscopy, the staining pattern for actin in the apical portion of Deiters cells corresponded with the location of the rosette complex. At the ultrastructural level, the actin antibodies bound selectively at the periphery of the dense trabeculae in the center of the complex. Comparative staining with a battery of polyclonal and isoform-specific monoclonal antibodies revealed selective presence of the gamma muscle actin isoform in this location. The loose meshwork at the periphery of the rosette complex stained selectively with a monoclonal antibody to vimentin. beta-tubulin was not associated with the rosette complex but occurred in abundance in the microtubule-rich stalk. Actin and vimentin were not detected in the apical compartment of Deiters cells at the extreme base of the cochlea, thus confirming their association with the rosette complex which is not present in regions of the gerbil cochlea tuned to frequencies of 20 kHz or higher (Spicer and Schulte, 1993, 1994). The cytoarchitecture of the rosette complex and its preferential distribution along the place-frequency map promote speculation that Deiters cells may play a role in regulating ion homeostasis and/or micromechanical response properties of the organ of Corti.
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