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  • Title: [Relation between grades of histologic differentiation and hormone receptors in breast cancer].
    Author: Nola N, Separović V, Sarcević B, Graf D, Petrinec Z, Matesa N, Kruslin B.
    Journal: Lijec Vjesn; 1995; 117(5-6):117-20. PubMed ID: 8600322.
    Abstract:
    The relationship between the grade of histologic differentiation of the tumor and estrogen (ER) and progesterone (PgR) receptor values was analyzed in 261 patients with breast cancer of the invasive duct type. There was a statistically significant difference in concentration and incidence of positive and negative ER and PgR with regard to histologic grade. The concentration and number of positive hormone receptors increased with better differentiation of the tumor. A statistically significant correlation between histologic grade, hormone receptor values and axillary nodal involvement was obtained only in patients with no metastases to axillary lymph nodes.
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