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  • Title: Role of intercellular interactions in heterosynaptic long-term depression.
    Author: Scanziani M, Malenka RC, Nicoll RA.
    Journal: Nature; 1996 Apr 04; 380(6573):446-50. PubMed ID: 8602244.
    Abstract:
    Bidirectional control of synaptic strength is thought to be important for the development of neuronal circuits and information storage. The demonstration of homosynaptic long-term depression greatly enhances the usefulness of the synapse as a mnemonic device, but theoreticians have also seen the need for heterosynaptic decreases in synaptic efficacy, both in neuronal development and information storage. Indeed, induction of long-term potentiation in one population of synapses can be associated with a modest depression at neighbouring inactive synapses in the same population of cells. Here we report that in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property that its sites of induction and expression occur in different populations of cells and thus requires the spread of a signal between neurons. Such a mechanism ensures a widespread distribution of this form of plasticity.
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