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  • Title: Serum sickness reaction following multiple insect stings.
    Author: Lazoglu AH, Boglioli LR, Taff ML, Rosenbluth M, Macris NT.
    Journal: Ann Allergy Asthma Immunol; 1995 Dec; 75(6 Pt 1):522-4. PubMed ID: 8603283.
    Abstract:
    BACKGROUND: Anaphylaxis is the most common systemic allergic reaction caused by stinging insects. Serum sickness reactions occur much less frequently. OBJECTIVE: To determine the level of venom-specific IgG and IgE antibodies during and after a serum sickness reaction to vespid venom. METHODS: Case report; ELISA determination of venom-specific IgG and IgE; complement levels and tests for immune complexes were performed. RESULTS: We report the case of a 66-year-old woman who developed a serum sickness reaction nine days after receiving multiple vespid stings. She developed urticaria, angioedema, fever, and arthralgias. She had elevated IgG and IgE venom-specific titers which declined during the recovery phase. Complement levels were normal and tests for immune complexes were negative. She was successfully treated with venom-specific immunotherapy without any serum sickness reaction. CONCLUSIONS: A serum sickness reaction with elevated venom-specific IgG and IgE is reported with successful immunotherapy.
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