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  • Title: Antibodies against the N-terminus of IL-8 receptor A inhibit neutrophil chemotaxis.
    Author: Quan JM, Martin TR, Rosenberg GB, Foster DC, Whitmore T, Goodman RB.
    Journal: Biochem Biophys Res Commun; 1996 Feb 15; 219(2):405-11. PubMed ID: 8605000.
    Abstract:
    Neutrophil migration and activation are the cornerstones of the acute inflammatory response. Interleukin-8 triggers several functions of neutrophils in host defense: chemotaxis, degranulation and enzyme release, and superoxide production. Interleukin-8 is most potent as a chemoattractant, so chemotaxis is likely the most important of these functions. The effects of interleukin-8 on neutrophils are mediated through two receptors, IL-8RA and IL-8RB. To investigate the role of these receptors in neutrophil chemotaxis, we produced inhibitory antibodies to IL-8RA. These antibodies inhibit neutrophil chemotaxis toward IL-8 in vitro. These findings show that IL-8RA mediates a chemotactic signal in neutrophils and suggest that an anti-receptor strategy may be a useful approach to limit neutrophil migration in inflammation.
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