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  • Title: The serum response factor (SRF) is needed for muscle-specific activation of CArG boxes.
    Author: Soulez M, Tuil D, Kahn A, Gilgenkrantz H.
    Journal: Biochem Biophys Res Commun; 1996 Feb 15; 219(2):418-22. PubMed ID: 8605002.
    Abstract:
    CArG boxes, whose consensus sequence is CC(A/T)6GG, are involved in two very different types of transcriptional responses: response of immediate early genes to serum, mediated by so-called Serum Response Elements (SRE), and transcriptional activation of muscle-specific genes during muscle differentiation. Although previous studies have shown that the Serum Response Factor (SRF) binds to muscular CArG boxes, the role of such a binding in muscle-specific activation of CArG box-dependent genes was not directly demonstrated. Here, by transient co-transfection experiments, we demonstrate that intact SRF is required for muscle-specific transcriptional activation through CArG boxes.
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