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  • Title: Rapid increase in plasma nitrite concentration following intravenous administration of nipradilol.
    Author: Adachi T, Hori S, Miyazaki K, Takahashi E, Nakagawa M, Udagawa A, Hayashi N, Aikawa N, Ogawa S.
    Journal: Eur J Pharmacol; 1995 Nov 14; 286(2):201-4. PubMed ID: 8605957.
    Abstract:
    Nipradilol, a beta-adrenoceptor antagonist with vasodilator activity, has a structure which contains a NO2 group. In anesthetized dogs, the time course of the systemic vasodilation and plasma nitrite (NO2-) concentration was studied following intravenous administration of nipradilol (1 mg/kg). A fall in systemic vascular resistance was observed at 1 min, which was rapidly followed by a significant increase in the plasma NO2- concentration. It is indicated that nipradilol exerts systemic vasodilatation via nitric oxide (NO) release in vivo.
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