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  • Title: Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum.
    Author: Nowak JZ, Maśliński C.
    Journal: Agents Actions; 1977 Mar; 7(1):27-30. PubMed ID: 860673.
    Abstract:
    Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine significantly reduced the histamine-induced increase of HVA. It is concluded that histamine primarily activates cholinergic neurons and that the changes in DA metabolism are a consequence of an increased cholinergic activity.
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