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  • Title: Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS.
    Author: Zakar T, Olson DM.
    Journal: Reprod Fertil Dev; 1995; 7(3):517-20. PubMed ID: 8606963.
    Abstract:
    The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation.
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