These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of vagal and laryngeal afferents on apnoeic response to serotonin in cats.
    Author: Szereda-Przestaszewska M, Wypych B.
    Journal: Respir Physiol; 1995 Sep; 101(3):231-7. PubMed ID: 8606996.
    Abstract:
    Intravenous serotonin (5-HT) elicits apnoea followed by subsequent, shallow tachypnoea. The present study was designed to ascertain whether laryngeal afferents play a role in the respiratory reflex response. Administration of 5-HT into the femoral vein (i.v.) or to the laryngeal artery (lar. art.) in anaesthetized, spontaneously breathing cats caused an expiratory apnoea that was significantly reduced (i.v.) or abolished (lar. art.) by bilateral midcervical vagotomy. Subsequent bilateral division of the superior laryngeal nerves (SLNs) did not affect the magnitude of apnoea on i.v. administration. Supranodose vagotomy abolished the occurrence of post-serotonin apnoea following i.v. injection, which is consistent with earlier results. During the phase of rapid, shallow breathing the peak respiratory airflows were significantly increased on i.v. 5-HT injection in all neural states of cats, whereas laryngeal artery administration failed to produce a significant change in respiration airflows from baseline. Serotonin significantly increased breathing frequency in the intact and denervated (vagus and SLN cut bilaterally) cats independent of the route of injection. The results show that serotonin effects the respiratory pattern with large contribution of pulmonary vagal but not laryngeal afferents. However, the occurrence of the expiratory apnoea was related to large extent to the integrity of the infranodose vagi.
    [Abstract] [Full Text] [Related] [New Search]