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  • Title: Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate.
    Author: Wu X, Somlyo AV, Somlyo AP.
    Journal: Biochem Biophys Res Commun; 1996 Mar 27; 220(3):658-63. PubMed ID: 8607821.
    Abstract:
    8-bromo-cyclic guanosine monophosphate (8-br-cGMP), at constant Ca2+, accelerated the dephosphorylation of the regulatory myosin regulatory light chain and relaxation of permeabilized rabbit ileum smooth muscle. These effects were independent of myosin light chain kinase activity. Similarly, 8-br-cGMP relaxed GTPgammaS-induced force and inhibited the GTPgammaS-induced increase in myosin light chain phosphorylation at constant [Ca2+]. We conclude that cyclic GMP-dependent kinase, activated by 8-br-cGMP, increases smooth muscle myosin light chain phosphatase activity and counteracts the inhibition of the latter enzyme by G-protein(s).
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