These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of sodium valproate on renal cell brush-border enzymes in rats.
    Author: Cepelak I, Rekić B, Juretić D, Mandusić A.
    Journal: Eur J Clin Chem Clin Biochem; 1995 Oct; 33(10):673-7. PubMed ID: 8608186.
    Abstract:
    The effect of sodium valproate (200 mg/kg body weight) on renal cells was investigated during a 10-day trial, by determining the catalytic activities of alanine aminopeptidase, gamma-glutamyltransferase and alkaline phosphatase in the membrane cell brush-border of the renal proximal tubules. Four days after the administration of sodium valproate, a significant increase was observed in the volume of urine (9.2 +/- 4.2 ml/18-h volume; control group, 3.06 +/- 1.8 ml/18-h volume), and in the catalytic activities of gamma-glutamyltransferase (2.69 times that measured in the control group) and alkaline phosphatase (3.02 times that measured in the control group) in urine. After prolonged treatment the urine became alkaline (pH = 10.5 on day 10), thereby excluding alanine aminopeptidase as a useful indicator of renal cell changes following the administration of sodium valproate. The activities of alkaline phosphatase and gamma-glutamyltransferase in isolated vesicles of renal brush-border membrane cells were significantly increased (p < 0.05) and decreased, respectively. On the basis of the results obtained, we believe that the determination of the catalytic activities of gamma-glutamyltransferase and alkaline phosphatase in urine might prove useful for the follow-up of the renal cell state during therapy with sodium valproate.
    [Abstract] [Full Text] [Related] [New Search]