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  • Title: Thyroid testing using the Cobas Core immunoassay system. A multicentre study.
    Author: Michotey O, Dörr R, Bourderont D, Gaya J, Rivera F, Benz R, Schmidt M.
    Journal: Eur J Clin Chem Clin Biochem; 1995 Sep; 33(9):609-22. PubMed ID: 8611671.
    Abstract:
    The random access immunoanalyzer Cobas Core and the Cobas Core Thyroid Assays were assessed as to their clinical usefulness in the analysis of different thyroid diseases. Four centres participated in this study measuring the following five thyroid tests per sample on the instrument: thyrotropin, free thyroxine, thyroxine, triiodothyronine and free triiodothyronine. The assessment was based on studies of precision and clinical samples. Within- and between-series precisions showed a mean CV over all assays of 4.3 and 6.1%, respectively. Comparison of the test results with clinical data demonstrated that the Cobas Core results are in accordance with diagnosed thyroid diseases. A good discrimination between normal and disease status and between untreated and treated status was found. Furthermore, 370 sera measured with Technicon Immuno-1 TSH and FT4 assays were compared to the respective Cobas Core EIAs). A good correlation between the assays was demonstrated.
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