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  • Title: Retrovirus envelope domain at 1.7 angstrom resolution.
    Author: Fass D, Harrison SC, Kim PS.
    Journal: Nat Struct Biol; 1996 May; 3(5):465-9. PubMed ID: 8612078.
    Abstract:
    We report the crystal structure of an extraviral segment of a retrovirus envelope protein, the Moloney murine leukemia virus (MoMuLV) transmembrane (TM) subunit. This segment, which comprises a region of the MoMuLV TM protein analogous to that contained within the X-ray crystal structure of low-pH converted influenza hemagglutinin, contains a trimeric coiled coil, with a hydrophobic cluster at its base and a strand that packs in an antiparallel orientation against the coiled coil. This structure gives the first high-resolution insight into the retrovirus surface and serves as a model for a wide range of viral fusion proteins; key residues in this structure are conserved among C- and D-type retroviruses and the filovirus ebola.
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