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  • Title: LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction.
    Author: Simske JS, Kaech SM, Harp SA, Kim SK.
    Journal: Cell; 1996 Apr 19; 85(2):195-204. PubMed ID: 8612272.
    Abstract:
    In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway. lin-2 and lin-7 mutants exhibit a vulvaless phenotype similar to the phenotype observed when this signaling pathway is defective. We have found that LIN-7 is a cell junction-associated protein that binds to the LET-23 receptor tyrosine kinase. LET-23 is also localized to the cell junctions, and both LIN-2 and LIN-7 are required for this localization. LET-23 overexpression rescues the lin-2 or lin-7 vulvaless phenotype, suggesting that increased receptor density can compensate for mislocalization. These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity.
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