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  • Title: Differential cellular localization of oestrogen receptor immunoreactivity and oxytocin mRNA and immunoreactivity in the rat preoptic area.
    Author: Cruttwell CJ, Herbison AE, Bicknell RJ.
    Journal: Neurosci Lett; 1995 Nov 17; 200(2):89-92. PubMed ID: 8614570.
    Abstract:
    Oestrogen influences both oxytocin mRNA and peptide immunoreactivity in the preoptic area and the rat oxytocin gene contains functional oestrogen response elements. However, using combinations of immunocytochemistry and in situ hybridization for oxytocin and oestrogen receptor, we found that preoptic oxytocin neurons do not possess oestrogen receptors. This finding implies oestrogen actions on oxytocin synthesis in preoptic neurones are unlikely to be mediated directly.
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