These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: In vitro antitumor activity of 4'-O-tetrahydropyranyladriamycin on human gastric cancer cells.
    Author: Yamaue H, Tanimura H, Noguchi K, Shono Y, Iwahashi M, Hotta T, Tani M, Tsunoda T, Nishimoto N, Terasawa H, Nakamori M.
    Journal: Anticancer Res; 1996; 16(1):243-6. PubMed ID: 8615614.
    Abstract:
    The antitumor activity of 4'-O-tetrahydropyranyladriamycin (THP-ADM) was assessed in established gastric cancer cell lines, including MKN-28, moderately differentiated adenocarcinoma and KATO-III, signet ring cell carcinoma and freshly excised human gastric cancer cells, using the MTT assay. The inhibition rates of THP-ADM were identical to those of adriamycin (ADM) in established gastric cancer cell lines, and the chemosensitivity of MKN-28 was higher than KATO-III. In fresh human gastric cancer cells obtained from 27 patients the inhibition rates of THP-ADM were identical to those of ADM, and there was a significant correlation of inhibition rates ADM and THP-ADM. These results indicate that THP-ADM should be a potent candidate to replace ADM in cancer chemotherapy.
    [Abstract] [Full Text] [Related] [New Search]